Aggravated Lyme Carditis in CD11a −/− and CD11c −/− Mice
نویسندگان
چکیده
منابع مشابه
Aggravated Lyme carditis in CD11a-/- and CD11c-/- mice.
CD18 hypomorph mice expressing reduced levels of the common beta2 integrin chain develop aggravated Lyme carditis, compared to that developed by wild-type (WT) mice, upon infection with the spirochete Borrelia burgdorferi. The enhancement of Lyme carditis in these mice is characterized by increased macrophage infiltration, correlating with augmented expression of the monocyte/macrophage chemoat...
متن کاملEarly recognition and management of Lyme carditis
A 20-year-old man presented to the emergency department with 2 weeks of migratory arthralgias and several macular blanching rashes. A photograph taken by the patient upon initial eruption of the rash was presented during evaluation (Fig. 1). The lesions were suspicious for erythema migrans (Fig. 2). Upon review of systems, the patient earlier reported a brief episode of palpitations. Electrocar...
متن کاملLyme Carditis in an Immunocompromised Patient
We present a case of a 68-year-old man with a history of liver transplant and of chronic immunosuppression therapy who presented to the emergency department (ED) for fevers and worsening fatigue for two days. On further investigation, the patient was found to have a new first-degree heart block on his electrocardiograph. Coupled with the history of a recent tick bite, the patient was diagnosed ...
متن کاملExpressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy
Objective(s):To examine the expressions of CD11a, CD11b, and CD11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. This study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. Materials and Methods: A myocardial hypertrophy model was established by subcutaneously injecting i...
متن کاملLyme Carditis Buried Beneath ST-Segment Elevations
Lyme disease is caused by the spirochete Borrelia burgdorferi and is carried to human hosts by infected ticks. There are nearly 30,000 cases of Lyme disease reported to the CDC each year, with 3-4% of those cases reporting Lyme carditis. The most common manifestation of Lyme carditis is partial heart block following bacterial-induced inflammation of the conducting nodes. Here we report a 45-yea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2005
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.73.11.7637-7643.2005